Detection of spreader nodes and ranking of interacting edges in Human-SARS-CoV protein interaction network

Sovan Saha; Piyali Chatterjee; Subhadip Basu; Mita Nasipuri

Spreader nodes and edges both play a crucial role in transmission of infection from one part of the network to another. Generally in a disease specific PPIN models, at least two entities are involved: one is pathogen/Bait and the other is host/Prey [31] . In this research work, SARS-CoV takes the role of the former while human later. SARS-CoV first transmits infection to its corresponding interaction human proteins which in turn affect its next level of proteins. So, the transmission occurs through connected nodes and edges. Not all the nodes or proteins in the PPIN transmit infection. So, proper identification of nodes transmitting infection (spreader nodes) is required. It is simultaneously also true that the transmission is not possible without the edges connecting two spreader nodes. Thus these connecting edges are called spreader edges. The proposed methodology involves a proper study and assessment of various existing established PPIN features followed by the identification of spreader nodes, which has been also verified by SIS model.