Author: Christine Dahlke; Jasmin Heidepriem; Robin Kobbe; Rene Santer; Till Koch; Anahita Fathi; My L. Ly; Stefan Schmiedel; Peter H. Seeberger; Marylyn M. Addo; Felix F. Loeffler
Title: Distinct early IgA profile may determine severity of COVID-19 symptoms: an immunological case series Document date: 2020_4_17
ID: icl1t9d6_32
Snippet: Both patients showed a similar viral load of SARS-CoV-2 following infection (Pfefferle et al., submitted) . While the proportion of plasmablasts was increased early after symptom onset and then decreased in patient #2 (very mild disease course), the relative plasmablast frequency further increased up to d16 in patient #1 (more severe disease course). After the disease had subsided (d32), the percentage of plasmablasts decreased. Similar observati.....
Document: Both patients showed a similar viral load of SARS-CoV-2 following infection (Pfefferle et al., submitted) . While the proportion of plasmablasts was increased early after symptom onset and then decreased in patient #2 (very mild disease course), the relative plasmablast frequency further increased up to d16 in patient #1 (more severe disease course). After the disease had subsided (d32), the percentage of plasmablasts decreased. Similar observations have been made in a study of a COVID-19 positive female patient, showing a peak of CD19+CD27+CD38+ cells in the blood at day 8 post disease onset, before symptoms were resolved. 8
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