Author: Weicheng Liang; Zhijie Feng; Shitao Rao; Cuicui Xiao; Zexiao Lin; Qi Zhang; Wei Qi
Title: Diarrhea may be underestimated: a missing link in 2019 novel coronavirus Document date: 2020_2_11
ID: bnv38la3_4
Snippet: In the current study, we found that the incidence of diarrhea differed significantly in three recent reports. As 2019-nCoV receptor ACE2 plays a role in intestinal inflammation and diarrhea, we subsequently evaluated the expression profiles of ACE2 by analyzing the RNA-sequencing and single-cell-sequencing data. We found that ACE2 was highly expressed in the small intestine, especially in the proximal and distal enterocytes. To sum up, we propose.....
Document: In the current study, we found that the incidence of diarrhea differed significantly in three recent reports. As 2019-nCoV receptor ACE2 plays a role in intestinal inflammation and diarrhea, we subsequently evaluated the expression profiles of ACE2 by analyzing the RNA-sequencing and single-cell-sequencing data. We found that ACE2 was highly expressed in the small intestine, especially in the proximal and distal enterocytes. To sum up, we proposed that ACE2-expressing small intestinal epithelium cells might be are more vulnerable to attack by 2019-nCoV and clinicians should be careful when their patients complain of diarrhea since the incidence of diarrhea may be underestimated.
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