Selected article for: "causative agent and coronavirus outbreak"
Author: Laura Riva; Shuofeng Yuan; Xin Yin; Laura Martin-Sancho; Naoko Matsunaga; Sebastian Burgstaller-Muehlbacher; Lars Pache; Paul P. De Jesus; Mitchell V. Hull; Max Chang; Jasper Fuk-Woo Chan; Jianli Cao; Vincent Kwok-Man Poon; Kristina Herbert; Tu-Trinh Nguyen; Yuan Pu; Courtney Nguyen; Andrey Rubanov; Luis Martinez-Sobrido; Wen-Chun Liu; Lisa Miorin; Kris M. White; Jeffrey R. Johnson; Christopher Benner; Ren Sun; Peter G. Schultz; Andrew Su; Adolfo Garcia-Sastre; Arnab K. Chatterjee; Kwok-Yung Yuen; Sumit K. Chanda
Title: A Large-scale Drug Repositioning Survey for SARS-CoV-2 Antivirals
  • Document date: 2020_4_17
    • ID: 1fgnfh62_1
    Snippet: In December 2019, the novel SARS coronavirus 2 (SARS-CoV-2) was identified as the causative agent of a severe pneumonia-like coronavirus disease (COVID- 19) outbreak in Wuhan in the Hubei province of China 1 . SARS-CoV-2 is an enveloped, positive-sense, single-stranded RNA betacoronavirus, related to the viruses that caused Notably, the levels of IL-6 have been reported to correlate with respiratory failure, and inhibitors are currently being pur.....
    Document: In December 2019, the novel SARS coronavirus 2 (SARS-CoV-2) was identified as the causative agent of a severe pneumonia-like coronavirus disease (COVID- 19) outbreak in Wuhan in the Hubei province of China 1 . SARS-CoV-2 is an enveloped, positive-sense, single-stranded RNA betacoronavirus, related to the viruses that caused Notably, the levels of IL-6 have been reported to correlate with respiratory failure, and inhibitors are currently being pursued in clinical studies for the amelioration of virusinduced inflammatory responses 7 . Patients with pre-existing chronic conditions such as hypertension, diabetes, and asthma, as well as those 65 years or older, are at a higher risk of severe disease outcome 8 . The underlying basis for these differential outcomes is yet unknown. Together, the still accelerating rate of community transmission and severity of the symptoms have placed an unprecedented burden on the medical supply chain and health care system in Italy, Spain, and the U.S. [9] [10] [11] , with similar scenarios playing out or anticipated in other countries.

    Search related documents:
    Co phrase search for related documents
    • accelerate rate and inflammatory response: 1
    • asthma diabetes and causative agent: 1
    • asthma diabetes and chronic condition: 1, 2, 3, 4, 5
    • asthma diabetes and clinical study: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11
    • asthma diabetes and community transmission: 1, 2, 3
    • asthma diabetes and health care: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
    • asthma diabetes and health care system: 1, 2, 3, 4, 5
    • asthma diabetes and high risk: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
    • asthma diabetes hypertension and causative agent: 1
    • asthma diabetes hypertension and chronic condition: 1
    • asthma diabetes hypertension and clinical study: 1, 2, 3, 4, 5, 6
    • asthma diabetes hypertension and community transmission: 1, 2, 3
    • asthma diabetes hypertension and health care: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13
    • asthma diabetes hypertension and health care system: 1
    • asthma diabetes hypertension and high risk: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12
    • asthma diabetes hypertension chronic condition and chronic condition: 1
    • causative agent and chronic condition: 1, 2
    • causative agent and clinical study: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
    • causative agent and community transmission: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11