Selected article for: "active compound and antibacterial activity"
Author: Laura Riva; Shuofeng Yuan; Xin Yin; Laura Martin-Sancho; Naoko Matsunaga; Sebastian Burgstaller-Muehlbacher; Lars Pache; Paul P. De Jesus; Mitchell V. Hull; Max Chang; Jasper Fuk-Woo Chan; Jianli Cao; Vincent Kwok-Man Poon; Kristina Herbert; Tu-Trinh Nguyen; Yuan Pu; Courtney Nguyen; Andrey Rubanov; Luis Martinez-Sobrido; Wen-Chun Liu; Lisa Miorin; Kris M. White; Jeffrey R. Johnson; Christopher Benner; Ren Sun; Peter G. Schultz; Andrew Su; Adolfo Garcia-Sastre; Arnab K. Chatterjee; Kwok-Yung Yuen; Sumit K. Chanda
Title: A Large-scale Drug Repositioning Survey for SARS-CoV-2 Antivirals
  • Document date: 2020_4_17
    • ID: 1fgnfh62_54
    Snippet: Tretinoin, clofazimine, acitretin were amongst the notable validated compounds, since they have been approved by the FDA. Clofazimine is a lipophilic riminophenazine antibiotic, with described antimycobacterial and anti-inflammatory activity 65 used for the treatment of leprosy. Main adverse effects include changes in skin pigmentation, nausea and vomiting. The antibacterial activity of clofazimine is described to be related to its ability to bin.....
    Document: Tretinoin, clofazimine, acitretin were amongst the notable validated compounds, since they have been approved by the FDA. Clofazimine is a lipophilic riminophenazine antibiotic, with described antimycobacterial and anti-inflammatory activity 65 used for the treatment of leprosy. Main adverse effects include changes in skin pigmentation, nausea and vomiting. The antibacterial activity of clofazimine is described to be related to its ability to bind to the bacterial DNA. Interestingly, this compound was also identified as a potent antiparasitic drug active against Cryptosporidium, during a repurposing screen of the ReFRAME library 30 . Further studies are required to understand the mechanism by which this molecule blocks the replication of this positive-strand RNA virus, and determination of the dose-response relationship for clofazimine will enable assessment of whether antiviral efficacy can be achieved at therapeutic doses. Acitretin is an approved orally bioavailable retinoid used for the treatment of psoriasis 66 .

    Search related documents:
    Co phrase search for related documents
    • adverse effect and antiviral efficacy: 1, 2, 3, 4
    • adverse effect and dose response: 1, 2
    • adverse effect and main adverse effect: 1, 2, 3, 4
    • adverse effect and RNA virus: 1, 2
    • adverse effect and therapeutic dose: 1, 2
    • adverse effect and vomiting nausea: 1, 2, 3
    • anti inflammatory activity and dose response: 1, 2
    • anti inflammatory activity and RNA virus: 1, 2, 3, 4
    • anti inflammatory activity and therapeutic dose: 1
    • anti inflammatory activity and validated compound: 1
    • anti inflammatory activity and vomiting nausea: 1, 2
    • antibacterial activity and RNA virus: 1
    • antiparasitic drug and ReFRAME library: 1
    • antiviral efficacy and dose response: 1, 2
    • antiviral efficacy and RNA virus: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24
    • antiviral efficacy and therapeutic dose: 1, 2
    • antiviral efficacy and vomiting nausea: 1