Diagnostic Indexes of a Rapid IgG/IgM Combined Antibody Test for SARS-CoV-2

Ying Liu; Yueping Liu; Bo Diao; Feifei Ren; Yue Wang; Jinya Ding; Qianchuan Huang

But how to detect early was an unmet demand in front of medical personnel. It is well known globally that virus nucleic acid high throughput sequencing or virus nucleic acid RT-PCR assay was the standard and recommended methods for detecting SARS-CoV-2, which caused COVID-19 pandemic across the whole world. High throughput sequencing can act as the 'golden standard' but it is highly restricted by its resource-dependent platform, especially in those resource-limited settings. Virus nucleic acid RT-PCR assay also suffer some limitations, long turnaround time, requirements for certified laboratories, skilled technicians and expensive equipment, and especially false negative results [5] . Generally speaking, RT-PCT results can be affected by many factors, such as quality of samples, degeneration of virus RNA, and improper sampling of nasal and pharyngeal swab. A former study revealed that 5 cases who were continuously PCR negative but with chest CT scan positive results were finally PCR confirmed positive after a series of continuous RT-PCR testing, which will inevitably hinder COVID-19 pandemic control and limit the outbreak containment effort [6] . This was in agreement with similar studies related to SARS in 2003, whose results showed that RT-PCR positive rate was only between 50% and 79% [7] . In addition, the number and variety of diagnostic tests should be expanded . CC-BY-NC-ND 4.0 International license It is made available under a author/funder, who has granted medRxiv a license to display the preprint in perpetuity.