Author: Ilda D’Annessa; Filippo Marchetti; Giorgio Colombo
Title: Differential Antibody Recognition by Novel SARS-CoV-2 and SARS-CoV Spike Protein Receptor Binding Domains: Mechanistic Insights and Implications for the Design of Diagnostics and Therapeutics Document date: 2020_3_14
ID: c08ptb1o_12
Snippet: Actually, except for the common topological localization, the predicted Ab-binding epitopes differ between the two proteins, both in their sequence and 3D structural organization (Table 1 , 2 and Figure 1 ). In some cases, linear sequences spanning distant segments of the primary structure come together in the three-dimensional structure to form extended substructures potentially (pre)organized for binding. This is particularly true for the confo.....
Document: Actually, except for the common topological localization, the predicted Ab-binding epitopes differ between the two proteins, both in their sequence and 3D structural organization (Table 1 , 2 and Figure 1 ). In some cases, linear sequences spanning distant segments of the primary structure come together in the three-dimensional structure to form extended substructures potentially (pre)organized for binding. This is particularly true for the conformational epitope at the N-and Cterminal region of SARS-CoV-2 RBD: the interacting region spans a large part of a well-defined betasheet subdomain (Table 1 , 2 and Figure 2 ). It is tempting to suggest that the expression of such subdomain in isolation could give rise to a highly immunoreactive molecule [19] [20] [21] .
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