Author: Rosenblat, Joshua D.; Lipsitz, Orly; Vincenzo, Joshua D. Di; Rodrigues, Nelson B.; Kratiuk, Kevin; Subramaniapillai, Mehala; Lee, Yena; Arekapudi, Anil K.; Abrishami, Amir; Chau, Edmond H.; Szpejda, Witold; Wong, Leslie; Mansur, Rodrigo B.; McIntyre, Roger S.
Title: Real-World Effectiveness of Repeated Ketamine Infusions for Treatment Resistant Depression During the COVID-19 Pandemic Cord-id: 3qequ1ap Document date: 2021_6_29
ID: 3qequ1ap
Snippet: Herein we evaluate the impact of COVID-19 restrictions on antidepressant effectiveness of intravenous (IV) ketamine in adults with treatment-resistant depression (TRD). We conducted a case series analysis of adults with TRD (n=268) who received four ketamine infusions at an outpatient clinic in Ontario, Canada, during COVID-19 restrictions (from March 2020 - February 2021; n = 160), compared to patients who received treatment in the previous year (March 2019 - February 2020; n = 108). Both group
Document: Herein we evaluate the impact of COVID-19 restrictions on antidepressant effectiveness of intravenous (IV) ketamine in adults with treatment-resistant depression (TRD). We conducted a case series analysis of adults with TRD (n=268) who received four ketamine infusions at an outpatient clinic in Ontario, Canada, during COVID-19 restrictions (from March 2020 - February 2021; n = 160), compared to patients who received treatment in the previous year (March 2019 - February 2020; n = 108). Both groups experienced significant and comparable improvements in depressive symptoms, suicidal ideation, and anxiety with repeated ketamine infusions. Effectiveness of IV ketamine was not attenuated during the COVID-19 period.
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