DREIMT: a drug repositioning database and prioritization tool for immunomodulation

Troulé, Kevin; López-Fernández, Hugo; García-Martín, Santiago; Reboiro-Jato, Miguel; Carretero-Puche, Carlos; Martorell-Marugán, Jordi; Martín-Serrano, Guillermo; Carmona-Sáez, Pedro; González-Peña, Daniel; Al-Shahrour, Fátima; Gómez-López, Gonzalo

Motivation Drug immunomodulation modifies the response of the immune system and can be therapeutically exploited in pathologies such as cancer and autoimmune diseases. Results DREIMT is a new hypothesis-generation web tool which performs drug prioritization analysis for immunomodulation. DREIMT provides significant immunomodulatory drugs targeting up to 70 immune cells subtypes through a curated database that integrates 4,960 drug profiles and ~2,6K immune gene expression signatures. The tool also suggests potential immunomodulatory drugs targeting user-supplied gene expression signatures. Final output includes drug-signature association scores, FDRs and downloadable plots and results tables. Availability http://www.dreimt.org Contact ;