Discovery of pharmaceutically-targetable pathways and prediction of survivorship for pneumonia and sepsis patients from the view point of ensemble gene noise

Tristan de Jong; Victor Guryev; Yury M. Moshkin

Second, high ranking gene ensembles (pathways) could be immediately associated with host response to infection and, thus, pathology of the sepsis. These include legionellosis (a pathway responsible for atypical pneumonia caused by Legionella bacteria), epithelial cell signalling in Helicobacter pylori infection and leishmaniasis, and imbalances in these pathways either caused by corresponding infections or immune activation could lead to the sepsis [38] [39] [40] . To that, ensemble gene noise in immune pathways, such as rheumatoid arthritis and primary immunodeficiency, contribute to the prediction of clinical outcome in sepsis patients ( Figure 3D , 5D and Table S3 ). Thus, we conclude that the ensemble gene noise uncovers novel approaches and insights to the discovery of biomarkers, prediction of clinical outcome and to the molecular mechanisms of a pathology from the point of view of imbalances in stoichiometry and gene noise of expression in gene ensembles.