Selected article for: "feature importance and statistical analysis"

Author: Chang, Amanda; Wang, Yi Grace; Jayanna, Manju B.; Wu, Xiaodong; Cadaret, Linda M.; Liu, Kan
Title: Mortality Correlates in Takotsubo Syndrome Patients during the COVID-19 Pandemic
  • Cord-id: 1dyjtdhw
  • Document date: 2021_9_29
  • ID: 1dyjtdhw
    Snippet: We completed a systematic review of published Takotsubo syndrome (TTS) cases during COVID-19 pandemic and performed clustering and feature importance analysis, and statistical testing for independence on the demographic, clinical and imaging parameters. Compared with the data before the COVID-19 pandemic, TTS was increasingly diagnosed in physical stress (mostly COVID-19 pneumonia)-triggered male patients without psychiatric/neurologic disorders, warranting further investigation to establish new
    Document: We completed a systematic review of published Takotsubo syndrome (TTS) cases during COVID-19 pandemic and performed clustering and feature importance analysis, and statistical testing for independence on the demographic, clinical and imaging parameters. Compared with the data before the COVID-19 pandemic, TTS was increasingly diagnosed in physical stress (mostly COVID-19 pneumonia)-triggered male patients without psychiatric/neurologic disorders, warranting further investigation to establish new reference criteria to improve diagnostic specificity. In clustering analysis, the gender and in-patient mortality primarily contributed to the automated classification of the TTS. Both the gender and in-patient mortality showed significant correlations with COVID-19 infection/pneumonia. There is effect modification of gender on outcomes in patients with COVID-19 infection and TTS, with male patients having significantly worse inpatient mortality. Meanwhile, significantly more male TTS patients were classified as “high-risk” following InterTAK prognostic scores, suggestive of male COVID-19/TTS survivors will likely have worse long-term outcome.

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