Author: Ilda D’Annessa; Filippo Marchetti; Giorgio Colombo
Title: Differential Antibody Recognition by Novel SARS-CoV-2 and SARS-CoV Spike Protein Receptor Binding Domains: Mechanistic Insights and Implications for the Design of Diagnostics and Therapeutics Document date: 2020_3_14
ID: c08ptb1o_10
Snippet: The application of MLCE to the Receptor Binding Domain (RBD, aa 319-591) of the SARS-CoV-2 spike protein (pdb code 6vsb; doi: 10.2210/pdb6vsb/pdb) 15 and of the SARS-CoV spike protein (pdb code 5x58; doi: 10.2210/pdb5X58/pdb) ( Figure 1 ) shows that the two protein regions that contain potential interaction regions/Ab-binding epitopes share the same topological localization at the two opposite ends of the 3D structures ( Figure 1 ). However, this.....
Document: The application of MLCE to the Receptor Binding Domain (RBD, aa 319-591) of the SARS-CoV-2 spike protein (pdb code 6vsb; doi: 10.2210/pdb6vsb/pdb) 15 and of the SARS-CoV spike protein (pdb code 5x58; doi: 10.2210/pdb5X58/pdb) ( Figure 1 ) shows that the two protein regions that contain potential interaction regions/Ab-binding epitopes share the same topological localization at the two opposite ends of the 3D structures ( Figure 1 ). However, this trait appears to be the only common one. The linear sequences that correspond to the predicted interacting epitope regions are reported in Table 1 .
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