Author: Christine Dahlke; Jasmin Heidepriem; Robin Kobbe; Rene Santer; Till Koch; Anahita Fathi; My L. Ly; Stefan Schmiedel; Peter H. Seeberger; Marylyn M. Addo; Felix F. Loeffler
Title: Distinct early IgA profile may determine severity of COVID-19 symptoms: an immunological case series Document date: 2020_4_17
ID: icl1t9d6_37
Snippet: We identified many spike protein epitopes that are bound by IgA antibodies, which might be crucial for neutralizing viral particles. Early and efficient binding of the spike protein by antibodies can limit viral spread following infection. We also identified several IgA epitopes in the spike protein, such as in the receptor binding domain (AA437-465) and in the fusion peptide domain (AA816-831). In addition, we also confirm parts of a SARS-CoV-2 .....
Document: We identified many spike protein epitopes that are bound by IgA antibodies, which might be crucial for neutralizing viral particles. Early and efficient binding of the spike protein by antibodies can limit viral spread following infection. We also identified several IgA epitopes in the spike protein, such as in the receptor binding domain (AA437-465) and in the fusion peptide domain (AA816-831). In addition, we also confirm parts of a SARS-CoV-2 and SARS-CoV cross-reactive IgG epitope (AA369-383) in the receptor binding domain of spike. 12
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