Author: Jiao Chen; Jiayu Shang; Jianrong Wang; Yanni Sun
Title: A binning tool to reconstruct viral haplotypes from assembled contigs Document date: 2019_7_16
ID: 2basllfv_61
Snippet: Overall, VirBin can cluster more contigs into their originating haplotypes than MaxBin. While VirBin focuses on sub-contigs that are more likely unique to one haplotype, MaxBin clusters whole contigs, which could contain regions common to multiple haplotypes and makes read coverage more heterogeneous. In addition, sequence composition-based features such as tetranucleotide frequencies are not effective in distinguishing highly similar viral strai.....
Document: Overall, VirBin can cluster more contigs into their originating haplotypes than MaxBin. While VirBin focuses on sub-contigs that are more likely unique to one haplotype, MaxBin clusters whole contigs, which could contain regions common to multiple haplotypes and makes read coverage more heterogeneous. In addition, sequence composition-based features such as tetranucleotide frequencies are not effective in distinguishing highly similar viral strains.
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