Author: Haixia Su; Sheng Yao; Wenfeng Zhao; Minjun Li; Jia Liu; Weijuan Shang; Hang Xie; Changqiang Ke; Meina Gao; Kunqian Yu; Hong Liu; Jingshan Shen; Wei Tang; Leike Zhang; Jianping Zuo; Hualiang Jiang; Fang Bai; Yan Wu; Yang Ye; Yechun Xu
Title: Discovery of baicalin and baicalein as novel, natural product inhibitors of SARS-CoV-2 3CL protease in vitro Document date: 2020_4_14
ID: ixun0c8g_10
Snippet: The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.04.13.038687 doi: bioRxiv preprint 2C and D, demonstrating a specific binding of baicalin or baicalein with the protease. Moreover, the plot of the fraction of the bound protease versus the total concentration of baicalin or baicalein obtained Kds of 12.73 and 1.40 µM for baicalin and baicalein, respectively ( Fig. 1E and F), in keeping wit.....
Document: The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.04.13.038687 doi: bioRxiv preprint 2C and D, demonstrating a specific binding of baicalin or baicalein with the protease. Moreover, the plot of the fraction of the bound protease versus the total concentration of baicalin or baicalein obtained Kds of 12.73 and 1.40 µM for baicalin and baicalein, respectively ( Fig. 1E and F), in keeping with the results from the ITC measurements.
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