Author: BALCIOĞLU, Bertan Koray; DENİZCİ ÖNCÜ, Melis; ÖZTÜRK, Hasan Ümit; YÜCEL, Fatıma; KAYA, Filiz; SERHATLI, Müge; ÜLBEĞİ POLAT, Hivda; TEKİN, Şaban; ÖZDEMİR BAHADIR, Aylin
Title: SARS-CoV-2 neutralizing antibody development strategies Cord-id: 1njdvnjw Document date: 2020_6_21
ID: 1njdvnjw
Snippet: In December 2019 a novel coronavirus was detected in Wuhan City of Hubei Province-China. Owing to a high rate of transmission from human to human, the new virus called SARS-CoV-2 differed from others by its unexpectedly rapid spread. The World Health Organization (WHO) described the most recent coronavirus epidemic as a global pandemic in March 2020. The virus spread triggered a health crisis (the COVID-19 disease) within three months, with socioeconomic implications. No approved targeted-therap
Document: In December 2019 a novel coronavirus was detected in Wuhan City of Hubei Province-China. Owing to a high rate of transmission from human to human, the new virus called SARS-CoV-2 differed from others by its unexpectedly rapid spread. The World Health Organization (WHO) described the most recent coronavirus epidemic as a global pandemic in March 2020. The virus spread triggered a health crisis (the COVID-19 disease) within three months, with socioeconomic implications. No approved targeted-therapies are available for COVID-19, yet. However, it is foreseen that antibody-based treatments may provide an immediate cure for patients. Current neutralizing antibody development studies primarily target the S protein among the structural elements of SARS-CoV-2, which mediates the cell entry of the virus through the angiotensin converting enzyme 2 (ACE2) receptor of host cells. This review aims to provide some of the neutralizing antibody development strategies for SARS-CoV-2 and in vitro and in vivo neutralization assays.
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