Selected article for: "low oxygen and lung injury"

Author: Hippchen, T.; Altamura, S.; Muckenthaler, M. U.; Merle, U.
Title: Hypoferremia predicts hospitalization and oxygen demand in COVID-19 patients
  • Cord-id: 0ygu5bu2
  • Document date: 2020_6_26
  • ID: 0ygu5bu2
    Snippet: Background: Iron metabolism might play a crucial role in cytokine release syndrome in COVID-19 patients. Therefore we assessed iron metabolism markers in COVID-19 patients for their ability to predict disease severity. Methods: COVID-19 patients referred to the Heidelberg University Hospital were retrospectively analyzed. Patients were divided into outpatients (cohort A, n=204), inpatients (cohort B, n=81), and outpatients later admitted to hospital because of health deterioration (cohort C, n=2
    Document: Background: Iron metabolism might play a crucial role in cytokine release syndrome in COVID-19 patients. Therefore we assessed iron metabolism markers in COVID-19 patients for their ability to predict disease severity. Methods: COVID-19 patients referred to the Heidelberg University Hospital were retrospectively analyzed. Patients were divided into outpatients (cohort A, n=204), inpatients (cohort B, n=81), and outpatients later admitted to hospital because of health deterioration (cohort C, n=23). Results: Iron metabolism parameters were severely altered in patients of cohort B and C compared to cohort A. In multivariate regression analysis including age, gender, CRP and iron-related parameters only serum iron and ferritin were significantly associated with hospitalization. ROC analysis revealed an AUC for serum iron of 0.894 and an iron concentration <6micromol/l as the best cutoff-point predicting hospitalization with a sensitivity of 94.7% and a specificity of 67.9%. When stratifying inpatients in a low- and high oxygen demand group serum iron levels differed significantly between these two groups and showed a high negative correlation with the inflammatory parameters IL-6, procalcitonin, and CRP. Unexpectedly, serum iron levels poorly correlate with hepcidin. Conclusion: We conclude that measurement of serum iron can help predicting the severity of COVID-19. The differences in serum iron availability observed between the low and high oxygen demand group suggest that disturbed iron metabolism likely plays a causal role in the pathophysiology leading to lung injury.

    Search related documents:
    Co phrase search for related documents
    • abnormally high and acute phase response: 1, 2
    • abnormally high and admission status: 1
    • abnormally high and liver damage: 1
    • abnormally high and low oxygen: 1
    • abnormally high and lung injury: 1, 2
    • acceptable specificity and acute ards respiratory distress syndrome: 1
    • acceptable specificity and admission time: 1
    • acceptable specificity and logistic regression: 1, 2