Author: Haixia Su; Sheng Yao; Wenfeng Zhao; Minjun Li; Jia Liu; Weijuan Shang; Hang Xie; Changqiang Ke; Meina Gao; Kunqian Yu; Hong Liu; Jingshan Shen; Wei Tang; Leike Zhang; Jianping Zuo; Hualiang Jiang; Fang Bai; Yan Wu; Yang Ye; Yechun Xu
Title: Discovery of baicalin and baicalein as novel, natural product inhibitors of SARS-CoV-2 3CL protease in vitro Document date: 2020_4_14
ID: ixun0c8g_9
Snippet: For the ligand-binding screening studies, two charge states (18+ and 19+) have been used for calculation of the free protease and protein-ligand complex intensities. The representative spectra of samples containing SARS-CoV-2 3CLpro (1 ïM) and baicalin (3.13 ïM) or baicalein (0.31 ïM) acquired under both optimized and screening conditions are shown in Fig. author/funder. All rights reserved. No reuse allowed without permission......
Document: For the ligand-binding screening studies, two charge states (18+ and 19+) have been used for calculation of the free protease and protein-ligand complex intensities. The representative spectra of samples containing SARS-CoV-2 3CLpro (1 ïM) and baicalin (3.13 ïM) or baicalein (0.31 ïM) acquired under both optimized and screening conditions are shown in Fig. author/funder. All rights reserved. No reuse allowed without permission.
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