Author: Xiao Huang; Jasper Z. Williams; Ryan Chang; Zhongbo Li; Eric Gai; David M. Patterson; Yu Wei; Wendell A. Lim; Tejal A. Desai
Title: DNA-scaffolded biomaterials enable modular and tunable control of cell-based cancer immunotherapies Document date: 2019_3_23
ID: 5bw7umap_22
Snippet: Given the ability to synthesize particles with ratiometric control of multiple surface cargos, we loaded anti-CD3 and anti-CD28 antibodies on AICE (PLGA microparticles) at varying ratios from 1:5 to 5:1. Anti-CD3/CD28 AICE were compared to commercial anti-CD3/CD28 Dynabeads at the same particle to cell ratio for the ability to expand human primary T cells with minimized differentiation and exhaustion (Fig. 3a) . Functionalized AICE activated T ce.....
Document: Given the ability to synthesize particles with ratiometric control of multiple surface cargos, we loaded anti-CD3 and anti-CD28 antibodies on AICE (PLGA microparticles) at varying ratios from 1:5 to 5:1. Anti-CD3/CD28 AICE were compared to commercial anti-CD3/CD28 Dynabeads at the same particle to cell ratio for the ability to expand human primary T cells with minimized differentiation and exhaustion (Fig. 3a) . Functionalized AICE activated T cells (Fig. 3b) and yielded higher or equivalent T cell expansion compared to Dynabeads expansion across three All rights reserved. No reuse allowed without permission.
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