Author: Chouaki Benmansour, Nassima; Carvelli, Julien; Vivier, Eric
Title: Complement cascade in severe forms of COVIDâ€19: Recent advances in therapy Cord-id: 1nqnu3lp Document date: 2021_4_10
ID: 1nqnu3lp
Snippet: The complement system is an essential component of the innate immune system. The three complement pathways (classical, lectin, alternative) are directly or indirectly activated by the SARSâ€CoVâ€2 (severe acute respiratory syndrome coronavirus 2). In the most severe forms of COVIDâ€19, overactivation of the complement system may contribute to the cytokine storm, endothelial inflammation (endotheliitis) and thrombosis. No antiviral drug has yet been shown to be effective in COVIDâ€19. Therefo
Document: The complement system is an essential component of the innate immune system. The three complement pathways (classical, lectin, alternative) are directly or indirectly activated by the SARSâ€CoVâ€2 (severe acute respiratory syndrome coronavirus 2). In the most severe forms of COVIDâ€19, overactivation of the complement system may contribute to the cytokine storm, endothelial inflammation (endotheliitis) and thrombosis. No antiviral drug has yet been shown to be effective in COVIDâ€19. Therefore, immunotherapies represent a promising therapeutic in the immunopathological phase (following the viral phase) of the disease. Complement blockade, mostly C5aâ€C5aR axis blockade, may prevent acute respiratory distress syndrome (ARDS) from worsening or progression to death. Clinical trials are underway.
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