Author: Roberto Balbontín; Nelson Frazão; Isabel Gordo
Title: DNA breaks-mediated cost reveals RNase HI as a new target for selectively eliminating antibiotic resistance Document date: 2019_9_5
ID: 5hfenevk_3
Snippet: We then hypothesized that, if DNA breaks are key contributors to the fitness cost of resistance, compensatory evolution of resistant strains should result in a reduction of DNA breaks. To test this, we compared the cost and SOS induction in the RpsL K43T RpoB H526Y double mutant and in an isogenic strain additionally carrying the most prevalent compensatory mutation found in our previous study:.....
Document: We then hypothesized that, if DNA breaks are key contributors to the fitness cost of resistance, compensatory evolution of resistant strains should result in a reduction of DNA breaks. To test this, we compared the cost and SOS induction in the RpsL K43T RpoB H526Y double mutant and in an isogenic strain additionally carrying the most prevalent compensatory mutation found in our previous study:
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