GeneCodis 4: Expanding the modular enrichment analysis to regulatory elements

García-Moreno, A.; López-Domínguez, R.; Ramirez-Mena, A.; Pascual-Montano, A.; Aparicio-Puerta, E.; Hackenberg, M.; Carmona-Saez, P.

GeneCodis is a web-based tool for functional enrichment analysis that allows researchers to integrate different sources of annotations. It extracts sets of significant concurrent annotations and assigns a statistical score to evaluate those that are significantly enriched in the input list. Since its first release in 2007, it has been widely employed to analyze lists of genes in order to interpret the underlying biological mechanisms. Here we present GeneCodis 4, a new release that expands the functional analysis provided by the application, to accept regulatory elements, including lists of, transcription factors, CpG sites and miRNAs. It also incorporates new annotation databases and improved interactive visualizations functionalities to explore results. GeneCodis 4 is freely available at https://genecodis.genyo.es.