Author: Roberto Balbontín; Nelson Frazão; Isabel Gordo
Title: DNA breaks-mediated cost reveals RNase HI as a new target for selectively eliminating antibiotic resistance Document date: 2019_9_5
ID: 5hfenevk_13
Snippet: RNase HI can serve as a target specific against resistant bacteria The large effect of lacking RNAse HI function on the fitness of resistant bacteria prompted us to ask whether targeting it could be used to select specifically against resistant bacteria in polymorphic populations. RNase HI inhibitors are currently studied as antiretrovirals (64) . A commercially available one, RHI001, has been shown to inhibit the activity of purified E. coli RNa.....
Document: RNase HI can serve as a target specific against resistant bacteria The large effect of lacking RNAse HI function on the fitness of resistant bacteria prompted us to ask whether targeting it could be used to select specifically against resistant bacteria in polymorphic populations. RNase HI inhibitors are currently studied as antiretrovirals (64) . A commercially available one, RHI001, has been shown to inhibit the activity of purified E. coli RNase HI protein in vitro (65) .
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