Author: Xiao Huang; Jasper Z. Williams; Ryan Chang; Zhongbo Li; Eric Gai; David M. Patterson; Yu Wei; Wendell A. Lim; Tejal A. Desai
Title: DNA-scaffolded biomaterials enable modular and tunable control of cell-based cancer immunotherapies Document date: 2019_3_23
ID: 5bw7umap_1
Snippet: avoid "on-target, off-tumor" toxicity in bystander healthy tissues 28 , CAR-T cells have been engineered with combinatorial antigen AND-gate activation control that requires sensing two antigens on a target cell to initiate killing. The clinical application of this strategy, however, requires systematic identification of tumor specific antigen combinations and would also benefit from better control of cell activity 27, 29 ......
Document: avoid "on-target, off-tumor" toxicity in bystander healthy tissues 28 , CAR-T cells have been engineered with combinatorial antigen AND-gate activation control that requires sensing two antigens on a target cell to initiate killing. The clinical application of this strategy, however, requires systematic identification of tumor specific antigen combinations and would also benefit from better control of cell activity 27, 29 .
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