Author: Woltemate, Thomas J.; Wadas, Richard J.; McCreary, Erin K.; Bariola, Ryan; Minnier, Tami; Marroquin, Oscar C.; Schmidhofer, Mark; Albin, Debbie; Angus, Derek C.; Yealy, Donald M.
Title: Emergency department implementation of monoclonal antibody infusion for the treatment of coronavirus disease 2019: A template for rapid deployment Cord-id: 1tjmftst Document date: 2021_9_17
ID: 1tjmftst
Snippet: Monoclonal antibody (mAb) therapy can improve coronavirus disease 2019 outcomes when infused early in select patients. We sought to rapidly create and implement a program for emergency department (ED) mAb infusion to aid care. Using multiple strategies and actions—education, selection criteria, screening tools, rapid testing, compounding, and delivery—we infused 832 ED patients with a mAb. The screening tool identified 94.5% of these patients as potential candidates. Length of stay was nearl
Document: Monoclonal antibody (mAb) therapy can improve coronavirus disease 2019 outcomes when infused early in select patients. We sought to rapidly create and implement a program for emergency department (ED) mAb infusion to aid care. Using multiple strategies and actions—education, selection criteria, screening tools, rapid testing, compounding, and delivery—we infused 832 ED patients with a mAb. The screening tool identified 94.5% of these patients as potential candidates. Length of stay was nearly identical for patients who tested positive for coronavirus disease 2019 versus those requiring testing. Mild adverse reactions occurred in 2.3% of mAb infusions, and severe reactions occurred in 0.5% of infusions. We highlight a strategic approach for using the ED as a key coronavirus disease 2019 therapeutic site for this intervention and with high utility and low disruption.
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