Selected article for: "resistant bacteria specific target and rnase HI function"
Author: Roberto Balbontín; Nelson Frazão; Isabel Gordo
Title: DNA breaks-mediated cost reveals RNase HI as a new target for selectively eliminating antibiotic resistance
  • Document date: 2019_9_5
    • ID: 5hfenevk_19
    Snippet: We revealed RNase HI as a promising target specific against resistant bacteria (Figure 4 ), and showed that lack of RNase HI function favors extinction of resistant clones, preventing compensatory evolution ( Figure 5A The copyright holder for this preprint (which was not peer-reviewed) is the author/funder. . https://doi.org/10.1101/756767 doi: bioRxiv preprint mutations (80) or for pathogens that acquire antibiotic resistance exclusively throug.....
    Document: We revealed RNase HI as a promising target specific against resistant bacteria (Figure 4 ), and showed that lack of RNase HI function favors extinction of resistant clones, preventing compensatory evolution ( Figure 5A The copyright holder for this preprint (which was not peer-reviewed) is the author/funder. . https://doi.org/10.1101/756767 doi: bioRxiv preprint mutations (80) or for pathogens that acquire antibiotic resistance exclusively through mutation, such as Mycobacterium tuberculosis, which often carries Rif R and Str R mutations (81) . Interestingly, RNase HI has been proposed as an antimycobacterial target due to its essentiality in Mycobacterium smegmatis (82, 83) . The results presented here strongly support the plausibility of this strategy.

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