Author: Roberto Balbontín; Nelson Frazão; Isabel Gordo
Title: DNA breaks-mediated cost reveals RNase HI as a new target for selectively eliminating antibiotic resistance Document date: 2019_9_5
ID: 5hfenevk_6
Snippet: We then hypothesized that, if DNA breaks contribute to the cost of resistance, enhancing DNA repair should reduce the cost. The RNA polymerase-binding transcription factor DksA has been recently shown to be involved in the transcription-coupled repair of DNA breaks (53, 54) . Thus, we hypothesize that overexpression of dksA should decrease the cost of resistance. As hypothesized, overproduction of DksA increases the fitness of the double resistan.....
Document: We then hypothesized that, if DNA breaks contribute to the cost of resistance, enhancing DNA repair should reduce the cost. The RNA polymerase-binding transcription factor DksA has been recently shown to be involved in the transcription-coupled repair of DNA breaks (53, 54) . Thus, we hypothesize that overexpression of dksA should decrease the cost of resistance. As hypothesized, overproduction of DksA increases the fitness of the double resistant RpsL K43N RpoB H526Y , but not that of sensitive bacteria ( Figure S2A ), indicating that the relationship between DNA breaks and the fitness cost of antibiotic resistance is, indeed, causal.
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