Author: Xiao Huang; Jasper Z. Williams; Ryan Chang; Zhongbo Li; Eric Gai; David M. Patterson; Yu Wei; Wendell A. Lim; Tejal A. Desai
Title: DNA-scaffolded biomaterials enable modular and tunable control of cell-based cancer immunotherapies Document date: 2019_3_23
ID: 5bw7umap_24
Snippet: [EMRA]), displayed a pattern ( Fig. 3f and Fig. Supplementary 3b) corresponding to the cell expansion trend among AICE with different anti-CD3 to anti-CD28 ratios ( Fig. 3c) . Through staining for T cell exhaustion markers LAG-3, PD-1 and TIM-3, we found that the population of exhausted cells at the optimal condition AICE- [3:1] was generally less than those activated by Dynabeads among the three donors ( Fig. Supplementary 3c,d) . Taken togeth.....
Document: [EMRA]), displayed a pattern ( Fig. 3f and Fig. Supplementary 3b) corresponding to the cell expansion trend among AICE with different anti-CD3 to anti-CD28 ratios ( Fig. 3c) . Through staining for T cell exhaustion markers LAG-3, PD-1 and TIM-3, we found that the population of exhausted cells at the optimal condition AICE- [3:1] was generally less than those activated by Dynabeads among the three donors ( Fig. Supplementary 3c,d) . Taken together, the data demonstrates that the surface ratio control of functional moieties on synthetic materials is important for the quantity and phenotype of cells yielded from ex vivo T cell expansion.
Search related documents:
Co phrase search for related documents- cell exhaustion and exhausted cell population: 1
- cell exhaustion and ratio control: 1
- cell exhaustion and synthetic material: 1
- cell expansion and optimal condition: 1
- cell expansion and ratio control: 1
- cell expansion and synthetic material: 1
- ratio control and synthetic material: 1
Co phrase search for related documents, hyperlinks ordered by date