Author: Xiao Huang; Jasper Z. Williams; Ryan Chang; Zhongbo Li; Eric Gai; David M. Patterson; Yu Wei; Wendell A. Lim; Tejal A. Desai
Title: DNA-scaffolded biomaterials enable modular and tunable control of cell-based cancer immunotherapies Document date: 2019_3_23
ID: 5bw7umap_27
Snippet: We also explored the use of AICE coated with an orthogonal antigen (GFP) to prime AND-gate CAR-T cell tumor recognition circuits, with the goal of preventing "ontarget off-tumor" toxicity by restricting cell killing to tumors locally-injected with AICE microparticles (Fig 4a) . These AND-gate T cells utilize a modular synthetic Notch (synNotch) receptor with an extracellular domain to recognize a target antigen, and an intracellular transcription.....
Document: We also explored the use of AICE coated with an orthogonal antigen (GFP) to prime AND-gate CAR-T cell tumor recognition circuits, with the goal of preventing "ontarget off-tumor" toxicity by restricting cell killing to tumors locally-injected with AICE microparticles (Fig 4a) . These AND-gate T cells utilize a modular synthetic Notch (synNotch) receptor with an extracellular domain to recognize a target antigen, and an intracellular transcriptional activator (TF) domain to control expression of a CAR targeting a second antigen 28 . Killing is only induced when both antigens are presented to T cells, with one activating the synNotch receptor to release the TF domain for CAR expression and the other activating CAR-mediated cytotoxicity 28 .
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