Selected article for: "activate complement and acute respiratory"

Author: Otieno, Steve Biko; Altahan, Alaa; Kaweeta, Fnu; Karri, Saradasri; Alnoor, Fnu; Johnson, Robert
Title: Severe Hemolysis in a COVID-19 Patient with Paroxysmal Nocturnal Hemoglobinuria
  • Cord-id: 0omrgb5g
  • Document date: 2021_7_13
  • ID: 0omrgb5g
    Snippet: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes coronavirus disease 2019 (COVID-19), has been demonstrated to be able to activate complement, making patients with deficiency in negative complement regulation, such as paroxysmal nocturnal hemoglobinuria (PNH), particularly vulnerable to complement-mediated cell damage. We report a case of a patient who presented with fatigue, facial swelling, and upper respiratory infection (URI) symptoms and was found to have
    Document: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes coronavirus disease 2019 (COVID-19), has been demonstrated to be able to activate complement, making patients with deficiency in negative complement regulation, such as paroxysmal nocturnal hemoglobinuria (PNH), particularly vulnerable to complement-mediated cell damage. We report a case of a patient who presented with fatigue, facial swelling, and upper respiratory infection (URI) symptoms and was found to have COVID-19 with laboratory tests showing severe hemolysis and pancytopenia secondary to PNH.

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