Author: Susmita Roy
Title: Dynamical asymmetry exposes 2019-nCoV prefusion spike Document date: 2020_4_22
ID: 29n9tsk9_11
Snippet: The synergy between internal RBD-hinge interactions and inter-chain interactions allows trimeric SARS-CoV-2 S to adopt a unique dynamical feature than other corona-virus spikes. It appears that the inter-chain interactions driven rapid symmetry breaking strategy potentiates this spike machine to turn on its high-infectivity. The energy landscape framework used in this study indeed helps to unify and compare different spike protein interactions pr.....
Document: The synergy between internal RBD-hinge interactions and inter-chain interactions allows trimeric SARS-CoV-2 S to adopt a unique dynamical feature than other corona-virus spikes. It appears that the inter-chain interactions driven rapid symmetry breaking strategy potentiates this spike machine to turn on its high-infectivity. The energy landscape framework used in this study indeed helps to unify and compare different spike protein interactions present in other coronaviruses. While in the current situation to develop diagnostics and antiviral therapies are of utmost priority, the present structure-based model derived information at the microscopic interaction level might provide deep insight to design effective decoys or antibodies to fight against 2019-nCoV infection. Supplementary Materials:
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