Impact of the COVID-19 pandemic on treatment patterns for US patients with metastatic solid cancer

Parikh, R. B.; Takvorian, S. U.; Vader, D.; Wileyto, E. P.; Clark, A. S.; Lee, D. J.; Goyal, G.; Rocque, G. B.; Dotan, E.; Geynisman, D. M.; Phull, P.; Spiess, P. E.; Kim, R. Y.; Davidoff, A. J.; Gross, C. P.; Neparidze, N.; Miksad, R. A.; Calip, G. S.; Hearn, C. M.; Ferrell, W.; Shulman, L. N.; Mamtani, R.; Hubbard, R. A.; Era, P.R.A.C.T.I.C.E Pandemic-Related Advanced Cancer Treatment In the COVID-19

Background: The COVID-19 pandemic has led to delays in patients seeking care for life-threatening conditions; however, its impact on treatment patterns for patients with metastatic cancer is unknown. We assessed the impact of the COVID-19 pandemic on time to treatment initiation (TTI) and treatment selection for patients newly diagnosed with metastatic solid cancer. Methods: We used an electronic health record-derived longitudinal database curated via technology-enabled abstraction to identify 14,136 US patients newly diagnosed with de novo or recurrent metastatic solid cancer between January 1 and July 31 in 2019 or 2020. Patients received care at ~280 predominantly community-based oncology practices. Controlled interrupted time series analyses assessed the impact of the COVID-19 pandemic period (April-July 2020) on TTI, defined as the number of days from metastatic diagnosis to receipt of first-line systemic therapy, and use of myelosuppressive therapy. Results: The adjusted probability of treatment within 30 days of diagnosis [95% confidence interval] was similar across periods: January-March 2019 41.7% [32.2%, 51.1%]; April-July 2019 42.6% [32.4%, 52.7%]; January-March 2020 44.5% [30.4%, 58.6%]; April-July 2020 46.8% [34.6%, 59.0%]; adjusted percentage-point difference-in-differences 1.4% [-2.7%, 5.5%]. Among 5,962 patients who received first-line systemic therapy, there was no association between the pandemic period and use of myelosuppressive therapy (adjusted percentage-point difference-in-differences 1.6% [-2.6%, 5.8%]). There was no meaningful effect modification by cancer type, race, or age. Conclusions: Despite known pandemic-related delays in surveillance and diagnosis, the COVID-19 pandemic did not impact time to treatment initiation or treatment selection for patients with metastatic solid cancers.