Selected article for: "hinge interaction and inter chain RBD interaction"
Author: Susmita Roy
Title: Dynamical asymmetry exposes 2019-nCoV prefusion spike
  • Document date: 2020_4_22
    • ID: 29n9tsk9_8
    Snippet: The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.04.20.052290 doi: bioRxiv preprint Fig. 4 : Interactions that make SARS-CoV-2 spike different from SARS-CoV and MERS-CoV spike. A. Unique inter-chain interactions formed by RBD of one chain with NTD of the adjacent chain stabilizing the S1-head-up conformation in SARS-CoV-2 S (pdb:6vsb). Interchain domain closure is analyzed by inter-chain p.....
    Document: The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.04.20.052290 doi: bioRxiv preprint Fig. 4 : Interactions that make SARS-CoV-2 spike different from SARS-CoV and MERS-CoV spike. A. Unique inter-chain interactions formed by RBD of one chain with NTD of the adjacent chain stabilizing the S1-head-up conformation in SARS-CoV-2 S (pdb:6vsb). Interchain domain closure is analyzed by inter-chain proline-proline distance measurement. The same distance measured for the following spikes: B. SARS-CoV spike (pdb:5x5b) and C. MERS-CoV spike (pdb: 5x5f). D. RBD up-down hinge dynamics triggered by inter-chain RBD-NTD domain interaction. E. In the absence of RBD-NTD inter-chain interaction, the hinge motion of RBD is hindered by populating more 'RBD-down' conformations and allows to sample 'RBD-up' conformation only rarely in a stochastic manner.

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