Author: Xiao Huang; Jasper Z. Williams; Ryan Chang; Zhongbo Li; Eric Gai; David M. Patterson; Yu Wei; Wendell A. Lim; Tejal A. Desai
Title: DNA-scaffolded biomaterials enable modular and tunable control of cell-based cancer immunotherapies Document date: 2019_3_23
ID: 5bw7umap_28
Snippet: Herein, human primary T cells were transduced with a gene encoding a constitutivelyexpressed synNotch receptor with an extracellular anti-GFP nanobody and an intracellular Gal4DBD-VP64 synthetic transcription factor (TF) domain, together with a TF-inducible CAR gene targeting HER2 (human epithelial growth factor receptor 2) 28 (Fig. 4a) . In this system, T cells should only express the anti-HER2 CAR and kill HER2 positive target cells after primi.....
Document: Herein, human primary T cells were transduced with a gene encoding a constitutivelyexpressed synNotch receptor with an extracellular anti-GFP nanobody and an intracellular Gal4DBD-VP64 synthetic transcription factor (TF) domain, together with a TF-inducible CAR gene targeting HER2 (human epithelial growth factor receptor 2) 28 (Fig. 4a) . In this system, T cells should only express the anti-HER2 CAR and kill HER2 positive target cells after priming via the anti-GFP synNotch binding AICE-presented GFP.
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