Effect of continuous renal replacement therapy on all-cause mortality in COVID-19 patients undergoing invasive mechanical ventilation: a retrospective cohort study

Yi Yang; Jia Shi; Shuwang Ge; Shuiming Guo; Xue Xing; Yanan Wang; Anying Cheng; Qingquan Liu; Junhua Li; Yong Ning; Fan He; Gang Xu

IL-1β is known as a lymphocyte-stimulating factor, produced by activated monocytemacrophages. 45, 46 It plays an immunomodulatory role to induce synthesis of acute phase protein causing fever and cachexia, active antigen-presenting cell and T cells, and promote the proliferation and secretion of antibodies of B cells in innate and acquired immunity. 47-49 IL-2 receptor is widely expressed on the surface of IL-2 target cells, including T cells, B cells, and monocyte macrophage, promoting cytotoxic action, secretion of the antibody, production of IFN-γ, TNF-β, TGF-β and non-specific cytotoxins. [50] [51] [52] Elevated levels of IL-1β and IL-2 receptor were associated with higher risk of all-cause mortality in patients with CRRT, indicating that overactive inflammation and immune responses might still be risk factors for death. Inflammatory mediators and biomarkers need to be timely monitored and other effective interventions need to be explored. All rights reserved. No reuse allowed without permission. the author/funder, who has granted medRxiv a license to display the preprint in perpetuity.