Effect of continuous renal replacement therapy on all-cause mortality in COVID-19 patients undergoing invasive mechanical ventilation: a retrospective cohort study

Yi Yang; Jia Shi; Shuwang Ge; Shuiming Guo; Xue Xing; Yanan Wang; Anying Cheng; Qingquan Liu; Junhua Li; Yong Ning; Fan He; Gang Xu

The copyright holder for this preprint (which was not peer-reviewed) is . https://doi.org/10.1101/2020.03. 16.20036780 doi: medRxiv preprint In our study, cTnI and NT-proBNP were associated with increased risk of mortality in patients with CRRT. cTnI, constituting cardiac troponin together with troponin T and C, is degraded from the cardiac muscle fiber in the event of myocardial cell injury. Elevated cTnI in serumreflects damage to cardiomyocytes with a high myocardial specificity. 53 Patients with increased cTnI levels showed higher in-ICU mortality of pneumonia. 54 NT-proBNP is a natural hormone with biological activity synthesized by cardiomyocytes and mainly expressed in the ventricle. The rapid synthesis and release of NT-proBNP into the blood due to myocardial dilation regulate the cardiac function among patients with left ventricular dysfunction. NT-proBNP cutoffs of 4000 pg/mL optimally predicted short-term mortality in patients with sepsis. 55 Therefore, COVID-19 patients with elevated cTnI and NT-proBNP should be given enough attention and active treatment.