Author: Xiao Huang; Jasper Z. Williams; Ryan Chang; Zhongbo Li; Eric Gai; David M. Patterson; Yu Wei; Wendell A. Lim; Tejal A. Desai
Title: DNA-scaffolded biomaterials enable modular and tunable control of cell-based cancer immunotherapies Document date: 2019_3_23
ID: 5bw7umap_50
Snippet: We believe that the true promise of the AICE platform will be realized by using particles to present multiple signals within the tumor microenvironment. AICE particles could kick-start tumor killing by triggering CAR expression by synNotch-CAR T cells. T cell activity within the tumor could be further augmented by cofunctionalization of AICE particles with additional cargos that go beyond a synNotch ligand, for instance, a costimulatory ligand an.....
Document: We believe that the true promise of the AICE platform will be realized by using particles to present multiple signals within the tumor microenvironment. AICE particles could kick-start tumor killing by triggering CAR expression by synNotch-CAR T cells. T cell activity within the tumor could be further augmented by cofunctionalization of AICE particles with additional cargos that go beyond a synNotch ligand, for instance, a costimulatory ligand and a checkpoint inhibitor tailored to circumvent the specific immune evasion mechanisms of a particular tumor type 17, 45 .
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