Author: Schutzer, Steven E; Body, Barbara A; Boyle, Jeff; Branson, Bernard M; Dattwyler, Raymond J; Fikrig, Erol; Gerald, Noel J; Gomes-Solecki, Maria; Kintrup, Martin; Ledizet, Michel; Levin, Andrew E; Lewinski, Michael; Liotta, Lance A; Marques, Adriana; Mead, Paul S; Mongodin, Emmanuel F; Pillai, Segaran; Rao, Prasad; Robinson, William H; Roth, Kristian M; Schriefer, Martin E; Slezak, Thomas; Snyder, Jessica L; Steere, Allen C; Witkowski, Jan; Wong, Susan J; Branda, John A
Title: Direct Diagnostic Tests for Lyme Disease Cord-id: 4ikzvnmv Document date: 2018_10_11
ID: 4ikzvnmv
Snippet: Borrelia burgdorferi was discovered to be the cause of Lyme disease in 1983, leading to seroassays. The 1994 serodiagnostic testing guidelines predated a full understanding of key B. burgdorferi antigens and have a number of shortcomings. These serologic tests cannot distinguish active infection, past infection, or reinfection. Reliable direct-detection methods for active B. burgdorferi infection have been lacking in the past but are needed and appear achievable. New approaches have effectively
Document: Borrelia burgdorferi was discovered to be the cause of Lyme disease in 1983, leading to seroassays. The 1994 serodiagnostic testing guidelines predated a full understanding of key B. burgdorferi antigens and have a number of shortcomings. These serologic tests cannot distinguish active infection, past infection, or reinfection. Reliable direct-detection methods for active B. burgdorferi infection have been lacking in the past but are needed and appear achievable. New approaches have effectively been applied to other emerging infections and show promise in direct detection of B. burgdorferi infections.
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