Author: Yu, Xiao; Cai, Baowei; Wang, Mingjun; Tan, Peng; Ding, Xilai; Wu, Jian; Li, Jian; Li, Qingtian; Liu, Pinghua; Xing, Changsheng; Wang, Helen Y.; Su, Xin-zhuan; Wang, Rong-Fu
Title: Cross-Regulation of Two Type I Interferon Signaling Pathways in Plasmacytoid Dendritic Cells Controls Anti-malaria Immunity and Host Mortality Cord-id: 14hraspn Document date: 2016_11_15
ID: 14hraspn
Snippet: Type I interferon (IFN) is critical for controlling pathogen infection; however, its regulatory mechanisms in plasmacytoid cells (pDCs) still remain unclear. Here, we have shown that nucleic acid sensors cGAS-, STING-, MDA5-, MAVS-, or transcription factor IRF3-deficient mice produced high amounts of type I IFN-α and IFN-β (IFN-α/β) in the serum and were resistant to lethal plasmodium yoelii YM infection. Robust IFN-α/β production was abolished when gene encoding nucleic acid sensor TLR7,
Document: Type I interferon (IFN) is critical for controlling pathogen infection; however, its regulatory mechanisms in plasmacytoid cells (pDCs) still remain unclear. Here, we have shown that nucleic acid sensors cGAS-, STING-, MDA5-, MAVS-, or transcription factor IRF3-deficient mice produced high amounts of type I IFN-α and IFN-β (IFN-α/β) in the serum and were resistant to lethal plasmodium yoelii YM infection. Robust IFN-α/β production was abolished when gene encoding nucleic acid sensor TLR7, signaling adaptor MyD88, or transcription factor IRF7 was ablated or pDCs were depleted. Further, we identified SOCS1 as a key negative regulator to inhibit MyD88-dependent type I IFN signaling in pDCs. Finally, we have demonstrated that pDCs, cDCs, and macrophages were required for generating IFN-α/β-induced subsequent protective immunity. Thus, our findings have identified a critical regulatory mechanism of type I IFN signaling in pDCs and stage-specific function of immune cells in generating potent immunity against lethal YM infection.
Search related documents:
Co phrase search for related documents- absence presence and adaptive immunity: 1, 2, 3, 4
- absence presence and adaptive innate: 1, 2
- absence presence and liver stage: 1
- absence presence and low amount: 1
- absence presence and lupus erythematosus: 1
- absence presence and lymph node: 1, 2, 3, 4, 5
- absence presence and macrophage colony: 1, 2
- absence presence and macrophage colony stimulating factor: 1, 2
- absence presence and macrophage depletion: 1
- activate ifn type and adaptor protein: 1, 2
- adaptive immune response and long recognize: 1
- adaptive immune response and lung immunopathology: 1, 2
- adaptive immune response and lupus erythematosus: 1
- adaptive immune response and lymph node: 1, 2, 3, 4, 5, 6
- adaptive immune response and macrophage colony: 1
- adaptive immune response and macrophage colony stimulating factor: 1
- adaptive immune response and macrophage critical role: 1
- adaptive immunity and lung immunopathology: 1
- adaptive immunity and lupus erythematosus: 1, 2, 3, 4, 5
Co phrase search for related documents, hyperlinks ordered by date