Selected article for: "hypothesis testing and multiple hypothesis testing"
Author: Tesfahun Dessale; Krishna Chaithanya Batchu; Diogo Barardo; Ng Li Fang; Vanessa Yuk Man Lam; Linfan Xiao; Markus R. Wenk; Nicholas S. Tolwinski; Jan Gruber
Title: Doubling healthy lifespan using drug synergy
  • Document date: 2017_6_21
    • ID: 9e3z9xdd_39
    Snippet: format. The RNAseq reads from each sample were mapped to the reference C. elegans 132 transcriptome (WBcel235) with kallisto (v0.43.0) 5 using 100 bootstrap samples and sequence 133 based bias correction. The estimated counts were imported from kallisto to the R environment 134 (v3.3.2) and summarized to gene-level using the tximport package (v1.2.0) 6 . The DESeq2 135 package (v1.14.1) 7 was used to identify differentially expressed genes (DEGs).....
    Document: format. The RNAseq reads from each sample were mapped to the reference C. elegans 132 transcriptome (WBcel235) with kallisto (v0.43.0) 5 using 100 bootstrap samples and sequence 133 based bias correction. The estimated counts were imported from kallisto to the R environment 134 (v3.3.2) and summarized to gene-level using the tximport package (v1.2.0) 6 . The DESeq2 135 package (v1.14.1) 7 was used to identify differentially expressed genes (DEGs) in all our 136 analysis (correcting for batch effects, when applicable) for a significance threshold α of 0.05 137 after correcting for multiple hypothesis testing through Independent Hypothesis Weighting 138 (IHW package v1.2.0) 8 . The PCA plot were graphed by the pcaExplorer package (v2.0.0) on 139

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