Author: Liu, Ke; Zou, Rongfeng; Cui, Wenqiang; Li, Meiqing; Wang, Xueying; Dong, Junlin; Li, Hongchun; Li, Hongpei; Wang, Peihui; Shao, Ximing; Su, Wu; Chan, H. C. Stephen; Li, Hongchang; Yuan, Shuguang
Title: Clinical HDAC Inhibitors Are Effective Drugs to Prevent the Entry of SARS-CoV2 Cord-id: 4mysvnlb Document date: 2020_11_10
ID: 4mysvnlb
Snippet: [Image: see text] The outbreak of COVID-19 by the end of 2019 has posed serious health threats to humanity and jeopardized the global economy. However, no effective drugs are available to treat COVID-19 currently and there is a great demand to fight against it. Here, we combined computational screening and an efficient cellular pseudotyped virus system, confirming that clinical HDAC inhibitors can efficiently prevent SARS-CoV-2 and potentially be used to fight against COVID-19.
Document: [Image: see text] The outbreak of COVID-19 by the end of 2019 has posed serious health threats to humanity and jeopardized the global economy. However, no effective drugs are available to treat COVID-19 currently and there is a great demand to fight against it. Here, we combined computational screening and an efficient cellular pseudotyped virus system, confirming that clinical HDAC inhibitors can efficiently prevent SARS-CoV-2 and potentially be used to fight against COVID-19.
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