Author: Alvim, R. G. F.; Lima, T. M.; Rodrigues, D. A. S.; Marsili, F. F.; Bozza, V. B. T.; Higa, L. M.; Monteiro, F. L.; Leitao, I. C.; Carvalho, R. S.; Galliez, R. M.; Castineiras, T. M. P. P.; Nobrega, A.; Travassos, L. H.; Ferreira, O. C.; Tanuri, A.; Vale, A. M.; Castilho, L. R.
Title: AN AFFORDABLE ANTI-SARS-COV-2 SPIKE ELISA TEST FOR EARLY DETECTION OF IgG SEROCONVERSION SUITED FOR LARGE-SCALE SURVEILLANCE STUDIES IN LOW-INCOME COUNTRIES Cord-id: 4nozg8uc Document date: 2020_7_15
ID: 4nozg8uc
Snippet: We describe a cost-effective, scalable technology to produce SARS-COV-2 spike (S) protein based on stable expression in HEK293 cells, and its use to develop a highly specific and sensitive ELISA test. The assay allows early detection of anti-S IgG seroconversion and endpoint titers correlate with virus neutralization. The low-cost S-antigen production, together with sample collection by finger prick and dried blood spots, allowed the development of a half-dollar test that fits the urgent need fo
Document: We describe a cost-effective, scalable technology to produce SARS-COV-2 spike (S) protein based on stable expression in HEK293 cells, and its use to develop a highly specific and sensitive ELISA test. The assay allows early detection of anti-S IgG seroconversion and endpoint titers correlate with virus neutralization. The low-cost S-antigen production, together with sample collection by finger prick and dried blood spots, allowed the development of a half-dollar test that fits the urgent need for large-scale serological surveillance in low-income countries.
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