Author: Chen, Mengyu; Qin, Rundong; Mei, Jiang; Yang, Zhaowei; Wen, Weiping; Li, Jing
Title: Clinical applications of detecting IgG, IgM, or IgA antibody for the diagnosis of COVID-19: A meta-analysis and systematic review Cord-id: 1clql98y Document date: 2021_1_12
ID: 1clql98y
Snippet: BACKGROUND: Coronavirus disease 2019 is a global pandemic. Serological antibody test is one important diagnostic method increasingly used in the clinic, although its clinical application is still under investigation. METHODS: We conducted a meta-analysis to compare the diagnostic performances of severe acute respiratory syndrome coronavirus 2 specific antibody tests in COVID-19 patients. Test results analyzed included (1) IgM-positive but IgG-negative (IgM(+)IgG-), (2) IgG-positive but IgM-negat
Document: BACKGROUND: Coronavirus disease 2019 is a global pandemic. Serological antibody test is one important diagnostic method increasingly used in the clinic, although its clinical application is still under investigation. METHODS: We conducted a meta-analysis to compare the diagnostic performances of severe acute respiratory syndrome coronavirus 2 specific antibody tests in COVID-19 patients. Test results analyzed included (1) IgM-positive but IgG-negative (IgM(+)IgG-), (2) IgG-positive but IgM-negative (IgG(+)IgM-), (3) both IgM and IgG-positive (IgM(+)IgG(+)), (4) IgM-positive without IgG information (IgM(+)IgG(+/-)), (5) IgG-positive without IgM information (IgG(+)IgM(+/-)), (6) either IgM or IgG-positive (IgM(+) or IgG(+)), and (7) IgA-positive (IgA(+)). RESULTS: Sixty-eight studies were included. The pooled sensitivities of IgM(+)IgG-, IgG(+)IgM-, IgM(+)IgG(+), IgM(+)IgG(+/-), IgG(+)IgM(+/-), and IgM(+) or IgG(+) were 6%, 7%, 53%, 68%, 73%, and 79% respectively. The pooled specificity ranged from 98% to 100%. The IgA(+) had a pooled sensitivity of 78%, but a relatively low specificity of 88%. Tests conducted two weeks after symptom onset provided improved diagnostic accuracy. Chemiluminescence immunoassay and detection of S protein as the antigen could offer a more accurate diagnostic result. DISCUSSION: Our findings support the supplemental role of serological antibody tests in COVID-19 diagnosis. However, their capacity to diagnose COVID-19 early in the disease course could be limited.
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