Selected article for: "acute respiratory distress syndrome and lung tissue"
Author: Obermayer, Astrid; Jakob, Lisa-Maria; Haslbauer, Jasmin D.; Matter, Matthias S.; Tzankov, Alexandar; Stoiber, Walter
Title: Neutrophil Extracellular Traps in Fatal COVID-19-Associated Lung Injury
  • Cord-id: 4kwwkn61
  • Document date: 2021_7_30
    • ID: 4kwwkn61
    Snippet: An excess formation of neutrophil extracellular traps (NETs), previously shown to be strongly associated with cytokine storm and acute respiratory distress syndrome (ARDS) with prevalent endothelial dysfunction and thrombosis, has been postulated to be a central factor influencing the pathophysiology and clinical presentation of severe COVID-19. A growing number of serological and morphological evidence has added to this assumption, also in regard to potential treatment options. In this study, w
    Document: An excess formation of neutrophil extracellular traps (NETs), previously shown to be strongly associated with cytokine storm and acute respiratory distress syndrome (ARDS) with prevalent endothelial dysfunction and thrombosis, has been postulated to be a central factor influencing the pathophysiology and clinical presentation of severe COVID-19. A growing number of serological and morphological evidence has added to this assumption, also in regard to potential treatment options. In this study, we used immunohistochemistry and histochemistry to trace NETs and their molecular markers in autopsy lung tissue from seven COVID-19 patients. Quantification of key immunomorphological features enabled comparison with non-COVID-19 diffuse alveolar damage. Our results strengthen and extend recent findings, confirming that NETs are abundantly present in seriously damaged COVID-19 lung tissue, especially in association with microthrombi of the alveolar capillaries. In addition, we provide evidence that low-density neutrophils (LDNs), which are especially prone to NETosis, contribute substantially to COVID-19-associated lung damage in general and vascular blockages in particular.

    Search related documents:
    Co phrase search for related documents
    • abundant presence and acute phase: 1
    • acetate pma and acute ards respiratory distress syndrome: 1
    • acetate pma and low density: 1, 2
    • acute ards respiratory distress syndrome and low density: 1, 2, 3, 4, 5, 6
    • acute ards respiratory distress syndrome and low density neutrophil: 1, 2, 3, 4
    • acute ards respiratory distress syndrome and lumen alveolar: 1, 2
    • acute ards respiratory distress syndrome and lung barrier dysfunction: 1, 2
    • acute phase and low density: 1, 2