Author: Tesfahun Dessale; Krishna Chaithanya Batchu; Diogo Barardo; Ng Li Fang; Vanessa Yuk Man Lam; Linfan Xiao; Markus R. Wenk; Nicholas S. Tolwinski; Jan Gruber
Title: Doubling healthy lifespan using drug synergy Document date: 2017_6_21
ID: 9e3z9xdd_29
Snippet: included. This approached culminated in the identification of 11 candidate drugs (Extended 43 data Table-1) . Primary efficacy was confirmed in terms of lifespan in C. elegans. Initial 44 screening of compounds for their effect on lifespan of wild type N2 nematodes were 45 conducted using standardized condition in the presence of antibiotics (200mg/ml 46 streptomycin). Of these 11 drugs and drug-like molecules, only five resulted in reproducible .....
Document: included. This approached culminated in the identification of 11 candidate drugs (Extended 43 data Table-1) . Primary efficacy was confirmed in terms of lifespan in C. elegans. Initial 44 screening of compounds for their effect on lifespan of wild type N2 nematodes were 45 conducted using standardized condition in the presence of antibiotics (200mg/ml 46 streptomycin). Of these 11 drugs and drug-like molecules, only five resulted in reproducible 47 lifespan extension in our lab (Fig. 1) . For those compounds that passed the primary screening, 48
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