Selected article for: "critical role and dusp1 impact"
Author: Alexa C. Robitaille; Elise Caron; Nicolas Zucchini; Espérance Mukawera; Damien Adam; Mélissa K. Mariani; Anaïs Gélinas; Audray Fortin; Emmanuelle Brochiero; Nathalie Grandvaux
Title: DUSP1 regulates apoptosis and cell migration, but not the JIP1-protected cytokine response, during Respiratory Syncytial Virus and Sendai Virus infection
  • Document date: 2017_7_13
    • ID: jzzhpw7h_18
    Snippet: JNK/p38 MAPK pathways are also known to play a critical role in the regulation of apoptosis, being either pro-or anti-apoptotic depending on the context [54] [55] [56] [57] [58] [59] . A MAVS/JNK pathway has been shown to be indispensable for SeV to induce apoptosis 60, 61 . Therefore, we sought to assess the impact of DUSP1 on the JNK/p38-dependent apoptosis triggered by SeV. A549 cells were transfected with siCtrl or siDUSP1 followed by treatme.....
    Document: JNK/p38 MAPK pathways are also known to play a critical role in the regulation of apoptosis, being either pro-or anti-apoptotic depending on the context [54] [55] [56] [57] [58] [59] . A MAVS/JNK pathway has been shown to be indispensable for SeV to induce apoptosis 60, 61 . Therefore, we sought to assess the impact of DUSP1 on the JNK/p38-dependent apoptosis triggered by SeV. A549 cells were transfected with siCtrl or siDUSP1 followed by treatment with DMSO (vehicle) or SP600125 and SB203580 to inhibit JNK and p38 before SeV infection. Quantification of Annexin V+ cells, corresponding to early and late apoptosis, was performed by Flow cytometry analysis of Annexin V/PI stained cells ( Figure 7A ). Confirming a moderate role of JNK/p38 in SeVinduced apoptosis, inhibition of JNK/p38 reduced the number of Annexin V+ cells by 12 %.

    Search related documents:
    Co phrase search for related documents
    • Annexin cell and critical role play: 1
    • Annexin cell and cytometry analysis: 1, 2, 3
    • apoptosis regulation and critical role: 1
    • apoptosis regulation and cytometry analysis: 1, 2
    • apoptosis regulation and late early apoptosis: 1
    • apoptosis regulation and MAPK pathway: 1, 2
    • critical role and cytometry analysis: 1
    • critical role and dusp1 impact: 1
    • critical role and MAPK pathway: 1, 2, 3, 4
    • critical role and sev infection: 1, 2
    • critical role play and MAPK pathway: 1, 2
    • critical role play and sev infection: 1
    • cytometry analysis and JNK apoptosis: 1
    • cytometry analysis and MAPK pathway: 1, 2
    • dusp1 impact and JNK apoptosis: 1
    • dusp1 impact and sev infection: 1, 2, 3, 4, 5
    • JNK apoptosis and sev infection: 1