Selected article for: "long qt interval and lopinavir ritonavir"
Author: Torres González, Nerea; Álvarez Acosta, Luis; Valdivia Miranda, Diego; Iriarte Plasencia, Alejandro; Barreto Cáceres, Virginia; Rivera Zambrano, Marx; Salvador Hernández Afonso, Julio
Title: Qt interval measurement with portable device during covid-19 outbreak
  • Cord-id: 4s3919mq
  • Document date: 2020_9_17
    • ID: 4s3919mq
    Snippet: Coronavirus Disease 2019 continues to spread and to date, no definitive treatment is available. Overcrowded and under-resourced healthcare centres have had to design different strategies to treat these patients, what includes the control of the electrocardiogram (ECG), as some drugs that have been used to treat these patients mayprolong the QT interval as a side effect. During the COVID-19 outbreak, we designed a protocol for monitoring the QT interval using a portable device with Bluetooth conn
    Document: Coronavirus Disease 2019 continues to spread and to date, no definitive treatment is available. Overcrowded and under-resourced healthcare centres have had to design different strategies to treat these patients, what includes the control of the electrocardiogram (ECG), as some drugs that have been used to treat these patients mayprolong the QT interval as a side effect. During the COVID-19 outbreak, we designed a protocol for monitoring the QT interval using a portable device with Bluetooth connectivity. After a validation study with 50 patients, we found a very good correlation between the QT interval measured both with this device and with the conventional body surface ECG. In this article, we provide a brief overview of the protocol and then analyse the QT changes observed in a group of patients during their hospitalization and treatment for SARS-CoV-2 infection. 81 patients with confirmed SARS-CoV-2 infection were enrolled in the protocol (age 63.4 SD 17.2 years; 70.3% men), while being treated with lopinavir/ritonavir, azithromycin and hydroxychloroquine, both individually or combined. Ten patients developed long drug-related QT interval, and the QT prolongation was statically significant for all treatment schemes, except for lopinavir/ritonavir alone. All patients with drug induced QT prolongation corrected the QT interval following the indications of the protocol, and no patients died of arrhythmic causes after its implementation. In our experience, a protocol for the electrocardiographic monitoring of these patients minimizes the risk of iatrogenic QT interval prolongation and consequently reduces sudden death events, and for that purpose, portable devices like the one used in this protocol may constitute a useful tool to minimize the contact with such patients.

    Search related documents:
    Co phrase search for related documents
    • acute respiratory and local problem: 1, 2, 3
    • acute respiratory and lopinavir hydroxychloroquine: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
    • acute respiratory and lopinavir ritonavir: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
    • acute respiratory and lopinavir ritonavir azithromycin: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
    • acute respiratory and lopinavir ritonavir azithromycin hydroxychloroquine: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
    • acute respiratory and lopinavir ritonavir azithromycin hydroxychloroquine qt interval: 1
    • acute respiratory and lopinavir ritonavir hydroxychloroquine azithromycin: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
    • acute respiratory and lopinavir ritonavir hydroxychloroquine azithromycin combination: 1, 2, 3, 4, 5, 6
    • acute respiratory and lopinavir ritonavir hydroxychloroquine azithromycin combination treat: 1, 2
    • acute respiratory and lopinavir ritonavir treat: 1, 2, 3, 4, 5, 6, 7
    • acute respiratory and lung superinfection: 1