Author: Susmita Roy
Title: Dynamical asymmetry exposes 2019-nCoV prefusion spike Document date: 2020_4_22
ID: 29n9tsk9_25
Snippet: A structure-based Hamiltonian of trimeric spike protein for SAR-CoV2 is derived using the super-symmetric contact map. In the current structure-based model amino acids are represented by single beads at the location of the C-α atom (15, 25, 31, 32) . The coarse-grained structurebased model, a well-established model, comprehends a novel way to investigate the mechanisms associated with protein folding and function (20-22, 24, 33-38) . In the curr.....
Document: A structure-based Hamiltonian of trimeric spike protein for SAR-CoV2 is derived using the super-symmetric contact map. In the current structure-based model amino acids are represented by single beads at the location of the C-α atom (15, 25, 31, 32) . The coarse-grained structurebased model, a well-established model, comprehends a novel way to investigate the mechanisms associated with protein folding and function (20-22, 24, 33-38) . In the current context of decoding virus entry mechanism, this model successfully characterized Class-I viral fusion protein dynamics including conformational rearrangement of a viral surface glycoprotein, influenza hemagglutinin (HA) during its prefusion and postfusion states (26, 39) .
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