Author: Yin Wang; Weiwei Jiang; Qi He; Cheng Wang; Baoju Wang; Pan Zhou; Nianguo Dong; Qiaoxia Tong
Title: Early, low-dose and short-term application of corticosteroid treatment in patients with severe COVID-19 pneumonia: single-center experience from Wuhan, China Document date: 2020_3_12
ID: 23mp5961_22
Snippet: The pathological process of severe COVID-19 pneumonia is the inflammation reaction characterized by destruction of deep airway and alveolar [6] . It is currently considered that the lung injury is not only associated with direct virus-induced injury, but also COVID-19 invasion triggers the immune responses that lead to the activation of immune cells(monocyte, macrophage, T and B-lymphocyte) to release a large number of pro-and anti-inflammatory c.....
Document: The pathological process of severe COVID-19 pneumonia is the inflammation reaction characterized by destruction of deep airway and alveolar [6] . It is currently considered that the lung injury is not only associated with direct virus-induced injury, but also COVID-19 invasion triggers the immune responses that lead to the activation of immune cells(monocyte, macrophage, T and B-lymphocyte) to release a large number of pro-and anti-inflammatory cytokines including TNF, IL-1β, IL-6 and so on. Overwhelming secretion of cytokines causes severe lung damage, which manifest as extensive damage of pulmonary vascular endothelial and alveolar epithelial cells as well as increased pulmonary vascular permeability, leading to the pulmonary edema and hyaline membrane formation [11, 12] . Histologic examination has shown diffuse alveolar damage and mucinous exudate, which similar to acute respiratory distress syndrome [6] .
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