Author: Kalinskaya, Anna; Dukhin, Oleg; Molodtsov, Ivan; Maltseva, Alexandra; Sokorev, Denis; Elizarova, Antonina; Sapozhnikova, Olga; Glebova, Ksenia; Stonogina, Daria; Shakhidzhanov, Soslan; Nikonov, Evgeniy; Mazus, Alexey; Spiridonov, Ilia; Ataullakhanov, Fazly; Margolis, Leonid; Shpektor, Alexander; Vasilieva, Elena
Title: Dynamics of coagulopathy in patients with different COVID-19 severity Cord-id: 2grh6gnz Document date: 2020_7_4
ID: 2grh6gnz
Snippet: With the progress of COVID-19 studies, it became evident that SARS-CoV-2 infection is often associated with thrombotic complications. The goal of our present study was to evaluate which component of clot formation process including endothelial function, platelets aggregation and plasma coagulation, as well as endogenous fibrinolysis in patients with COVID-19 correlates with the severity of the disease. We prospectively included 58 patients with COVID-19 and 47 healthy volunteers as a control gro
Document: With the progress of COVID-19 studies, it became evident that SARS-CoV-2 infection is often associated with thrombotic complications. The goal of our present study was to evaluate which component of clot formation process including endothelial function, platelets aggregation and plasma coagulation, as well as endogenous fibrinolysis in patients with COVID-19 correlates with the severity of the disease. We prospectively included 58 patients with COVID-19 and 47 healthy volunteers as a control group that we recruited before the pandemic started. It turns out that plasma coagulation with subsequent platelet aggregation, but not endothelial function, correlates with the severity of the COVID-19. IL-6 blockade may play a beneficial role in COVID-19 induced coagulopathy.
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